Ethyl 4-bromopyridine-3-carboxylate CAS 1092353-02-0

Ethyl 4-bromopyridine-3-carboxylate

The CAS number for Ethyl 4-bromopyridine-3-carboxylate is 1092353-02-0

The Molecular Formula of Ethyl 4-bromopyridine-3-carboxylate is C8H8BrNO2

Ethyl 4-bromopyridine-3-carboxylate

CAS 1092353-02-0

As an important pharmaceutical intermediate, 4-bromo-3-pyridinecarboxylic acid ethyl ester is widely used in the synthesis of anticancer drugs. The following are several types of anticancer drugs that it may participate in the synthesis and their mechanisms of action:

1. Kinase inhibitor drugs

EGFR inhibitors: used to treat cancers such as non-small cell lung cancer.

The role of 4-bromo-3-pyridinecarboxylic acid ethyl ester: As a pyridine structural unit, it participates in the construction of the parent nucleus structure of kinase inhibitors.

2. PARP inhibitors
Mechanism of action: PARP (poly ADP-ribose polymerase) inhibitors inhibit DNA repair mechanisms, causing cancer cells to die due to accumulation of DNA damage, especially for cancers with BRCA gene mutations (such as breast cancer and ovarian cancer).

Olaparib: used to treat BRCA mutation-related breast cancer and ovarian cancer.

Role of 4-bromo-3-picolinic acid ethyl ester: as a key intermediate for the synthesis of PARP inhibitors, it provides a pyridine ring structure.

3. Tubulin inhibitors

Role of 4-bromo-3-picolinic acid ethyl ester: as an intermediate for the synthesis of tubulin inhibitors, it participates in the construction of heterocyclic structures in drug molecules.

4. HDAC inhibitors

Vorinostat: used to treat cutaneous T-cell lymphoma.

Role of 4-bromo-3-picolinic acid ethyl ester: as an intermediate for the synthesis of HDAC inhibitors, it provides a pyridine ring structure.

5. Immune checkpoint inhibitor adjuvant drugs
Mechanism of action: Enhance the efficacy of immune checkpoint inhibitors (such as PD-1/PD-L1 inhibitors) by regulating the immune microenvironment.

Role of 4-bromo-3-pyridinecarboxylic acid ethyl ester: as a key intermediate for the synthesis of IDO inhibitors.

6. Other targeted drugs
Mechanism of action: small molecule targeted drugs designed for specific molecular targets (such as mTOR, PI3K, etc.).

Role of 4-bromo-3-pyridinecarboxylic acid ethyl ester: as an intermediate for the synthesis of targeted drugs, providing pyridine ring structure.

4-bromo-3-pyridinecarboxylic acid ethyl ester is mainly used to construct pyridine ring structure in the synthesis of anticancer drugs, and participates in the synthesis of various anticancer drugs such as kinase inhibitors, PARP inhibitors, tubulin inhibitors, and HDAC inhibitors. Its importance lies in providing a key heterocyclic skeleton for drug molecules, thereby affecting the targeting and biological activity of the drug.

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